Which factor can potentiate the hypotensive effect of GTN?

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Prepare for the Foundation Year Pharmacy Exam. Study with flashcards and multiple-choice questions. Each question comes with hints and explanations. Ensure your readiness for the exam!

Multiple Choice

Which factor can potentiate the hypotensive effect of GTN?

Explanation:
GTN lowers blood pressure by releasing nitric oxide, causing vasodilation and reduced preload and afterload. Alcohol adds to this effect because it also causes peripheral vasodilation and can blunt reflex compensatory responses, so the combination can produce a greater drop in blood pressure. Paracetamol and ibuprofen don’t enhance nitrate-induced vasodilation, and caffeine tends to raise BP rather than potentiate hypotension, making alcohol the factor that can potentiate GTN’s hypotensive effect.

GTN lowers blood pressure by releasing nitric oxide, causing vasodilation and reduced preload and afterload. Alcohol adds to this effect because it also causes peripheral vasodilation and can blunt reflex compensatory responses, so the combination can produce a greater drop in blood pressure. Paracetamol and ibuprofen don’t enhance nitrate-induced vasodilation, and caffeine tends to raise BP rather than potentiate hypotension, making alcohol the factor that can potentiate GTN’s hypotensive effect.

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